We begin from the patients in the blood containing the malaria parasite (stage Gametosit micro and macro). Anopheles mosquito (female) to suck the blood of patients and was carried into the stomach gametosit mosquitoes. Micro (male cells) and Makrogametosit (female cells) to mate and form Zygote and migration through the stomach wall to form a Ookinet and sporulation selajutnya form Sporosoit mosquitoes spread throughout the body, especially in the Anopheles mosquito salivary glands. Time required to multiply in the body since the mosquitoes until ready to be transmitted in the salivary glands of about 7 - 14 days (depending on the type of plasmodium and environmental conditions).
Mosquitoes containing sporosoit (infective) in the saliva glands going to bite a healthy person and let sporosoit into the bloodstream and then hide in the liver cells to perform the multiplication and release stage merosoit into the bloodstream and enter cells, red blood cells. Incubation time in the liver cells is about 6 - 8 days.
Merosoit phase Palsmodium cells into red blood cells and will turn into phase trofosoit / ring / ring and Schizont phase. The laboratory will usually identify this phase in the cell, red blood cells. From one merosoit can flourish and broke into 16 to 32 merosoit depending on the type Plasmodiumnya. At the time thousands of red blood cells rupture that we will shiver.
Time since the infective Anopheles mosquito bite until disease symptoms appear (incubation period) of about 9 to 40 days depending on the type of Plasmodium and lingkungannya.Sekitar conditions one week after a person has malaria would be formed and makrogametosit micro phase and this is a phase that can be transmitted to mosquitoes.
* P falciparum from 9 to 14 day incubation period
* P vivax 12 to 17 day incubation period
* P ovale from 12 to 17 day incubation period
* P malariae 18 to 40 day incubation period
On the type of Plasmodium vivax, some merosoit will hide and multiply in the spleen and stay latent for several years. This is what causes a person sick with malaria again despite no longer being bitten by mosquitoes such as ni Anopheles.Keadaan called recurrence or relapse.
On the type of Plasmodium falciparum, can cause cerebral (brain) and symptoms of malaria are so great that often cause the death of the patient. But when you are finished / successful treatment of patients will recover fully and do not relapse.
Plasmodium breeding mosquitoes in the body where there is a process of micro and makrogametosit marriage known sexual cycle, while proliferation in the human body which does not occur is called the marriage a sexual cycle.
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